Current Issue : October - December Volume : 2017 Issue Number : 4 Articles : 6 Articles
Background: Botulinum toxin A has been in used for more than 20 years for aesthetics. In Italy was firstly approved in 2004. From the very first moment I was using\nAbobolutimun Toxin A (Dysport and Azzalure) for aesthetical reasons. The use of Abobotulinum Toxin A (AboTA), the conversion rate with other toxins, its dilution\nand units used are still today not totally known by many specialists of the field.\nObjective: assess and update the perfect use of AboTA and fillers for facial rejuvenation\nMaterial and methods: literature has been reviewed (Pub Med, Med line, books) using main database and published books and compared with the personal modalities\nof using Speywood units of AboTA for cosmetical indications in face. Fillers are very important in the restoration of lost volumes.\nDiscussion: AboTA is a safe and very good drug for wrinkling treatment. All side effects are related to bad techniques, mistakes in the use, depth of injections. If\nwell used, AboTA is very safe and a very well performing drug. The integration with fillers is highly recommended to achieve natural and effective results. Only best\nfillers must be used.\nConclusions: AboTA, is a safe drug, with very good results. Side effects can be avoided only with a perfect anatomical knowledge, perfect depth of injections and\nprudential utilization of Units. Fillers must be used safely and the use of Hyaluronidase must be known by all aesthetic doctors....
Ginseng leaves contain high saponin composition and content, but are used less often\nthan the root part. To develop a use for the leaves that exploits their properties, we studied ginseng\nleaves as the raw material of anti-aging cosmetics. This study highlights an assessment of the cellular\nfactivity and clinical efficacy of ginseng leaf extract, providing necessary information relevant to the\ndevelopment of new cosmetic products. Panax ginseng leaf purified extracts (PGLE) were shown\nto have high contents of Rb3 and Rb2. Rb3, the major chemical components of PGLE, promoted\ncollagen synthesis though the activation of transforming growth factor-�² (TGF-�²) in human skin\nfibroblast cells. In addition, the possibility of PGLE as an anti-skin-aging agent has also been clinically\nvalidated. Our analysis of the crowâ��s feet wrinkle showed that there was a decrease in the depth\nof deep furrows in the region of interest (RI) treated with PGLE lotion over an eight-week period.\nBased on these results, we suggest the possibility that PGLE, having high levels of Rb3, be considered\nas an attractive, wrinkle-reducing candidate for topical application....
The date palm fruit (Phoenix dactylifera L. Arecaceae) is used in most of the countries of the\nworld and is an essential part of the diet, especially in many Arabian countries. Phoenix dactylifera L.\nfruits are a rich source of sugars (glucose and fructose), vitamins (A, C, and B complex), fibers,\nminerals, and phenolic compounds having antioxidant and anti-inflammatory properties. This study\nis designed to explore the Phoenix dactylifera L. fruit for skin care. A single-blinded, placebo control\ntrial was conducted, including 11 healthy female volunteers after their informed consent. The efficacy\nof the Phoenix dactylifera L. extract (4%) was evaluated in cream form after one, two, three, four, six,\nand eight weeks of treatment compared with the baseline. Prior to the study, the composition of\nthe extract was analyzed to understand the underlying mechanisms by which the extract affects\nskin. Treating facial skin with the Phoenix dactylifera L. extract significantly improved all parameters\ninvestigated, such as skin elasticity, pigmentation, redness, brightness, and hydration and led to\nthe improvement of the facial skin. There were no adverse reactions noted during the course of the\npatch test, demonstrating that the extract could be safe to apply on the skin. The Phoenix dactylifera L.\nfruit extract serves as a skin care ingredient that significantly improves characteristics important for\nperception of skin ageing and health. The efficacy of the treatment is possibly due to a combination\nof numerous active substances found in the Phoenix dactylifera L. extract....
Antioxidant neutralizes free radicals, unstable oxygen molecules that break down skin cells and cause wrinkles, thus preventing impairment at the cellular level. In the present work, face cream formulations were prepared using antioxidant from natural source. Raspberry extract and grape seed extract was used. Radical scavenging activity of raspberry, grape seeds was studied with standard ascorbic acid by DPPH method. Six cream base formulations were prepared and two formulations BF1 and BF4 were optimized. Six formulations of antioxidant cream were prepared using 2% extract. The various evaluation test like, pH, viscosity, grittiness, spreadability, skin irritation and antimicrobial test were carried out. The stability study over one week was also conducted. Raspberry and grapes seeds showed very good antioxidant activity with IC50 value 0.033 µg/ml and 0.072 µg/ml respectively. Face cream formulation shown active zone of inhibition within range of 9-12 mm, indicating that, all the formulation have good preservation activity. The study was concluded with that, natural source for excipient is the more suitable due to easy availability, non-toxicity and biocompatible properties of excipient. After studying the physical parameters, stability study evaluation, it was concluded that the product has the best capacity to reduce free radical and can be used as the provision of a barrier to protect skin....
The sun-and-skin interactions have controversial sides. Besides important beneficial\neffects, we need to take into consideration also some serious harmful results. In particular, these\nare connected to the portion of the solar spectrum traditionally identified as ultraviolet type A and\nB. The topical application of sunscreens (and the avoidance of extreme exposure to sun rays) is\nworldwide recognized as the best strategy to avoid sunburn and oedema. Moreover, such strategy\ncan efficiently prevent the onset of skin cancer. Therefore, the first aim of sunscreen products is\nto efficiently minimize all damage of sun exposure, while, at the same time, keeping good skin\ntolerability, avoiding safety problems and developing pleasant sensorial properties. Sunscreens, i.e.,\nsubstances able to reflect and/or absorb, at a partial or complete extent, UV radiation are the key\nactors in skin protection. They are used to implement the level of primary photoprotection against\nUV rays. This means that when they absorb the radiation energy, their molecules pass to an excited\nstate and successively re-emit energy in other forms (vibrational, rotational, infrared radiation) to\ncome back to the ground state....
In the last two decades, many new peptides have been developed, and new knowledge on\nhow peptides improve the skin has been uncovered. The spectrum of peptides in the field of cosmetics\nis continuously growing. This review summarizes some of the effective data on cosmeceutical\npeptides that work against intrinsic and extrinsic aging. Some peptides have been proven in their\nefficacy through clinical skin trials. Well-known and documented peptides like copper tripeptide\nare still under research to obtain more details on their effectiveness, and for the development of\nnew treatments. Palmitoyl pentapeptide-4 and Carnosine are other well-researched cosmeceuticals.\nAdditionally, there are many more peptides that are used in cosmetics. However, study results for\nsome are sparse, or have not been published in scientific journals. This article summarizes topical\npeptides with proven efficacy in controlled in vivo studies....
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